Synonyms | MonoclonalFBXL4antibody,Anti-FBXL4antibody,FBXL-4antibody,F-boxandleucine-richrepeatprotein4antibody,FBXL4,FBXL-4,FBXL4,FBL5antibody,FBL4antibody,FBXL4antibody |
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Specificity | HumanFBXL4 |
CrossReactivity | Human.Otherspeciesnotstudied |
Applications | DotBlot |
Immunogen | FBXL4antibodywasraisedinmouseusingrecombinantHumanF-BoxAndLeucine-RichRepeatProtein4(Fbxl4) |
Host | Mouse |
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Clone | 2352C1a |
Isotype | IgG1 |
MethodofPurification | FBXL4antibodywaspurifiedusingproteinGcolumnchromatographyfromculturesupernatantofhybridomaculturedinamediumcontainingbovineIgG-depleted(approximately95%)fetalbovineserum. |
Form&Buffer | FBXL4antibodyinPBS(3.0mMKCl,1.5mMKH2PO4,140mMNaCl,8.0mMNa2HPO4(pH7.4))containing1%bovineserumalbumin(BSA)and0.05%sodiumazide(NaN3). |
Concentration | 100ug/ml |
Storage | Storeat2-8degCforuptooneyear.Werecommendlongtermstorageat-20degC.Avoidrepeatedfreezingandthawing. |
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BiohazardInformation | Thisantibodysolutioncontainssodiumazide(NaN)asapreservative.ThereisapotentialhazardthatNaNreactswithcopperorleadtoproduceanexplosivecompound.Forsafedisposal,thevialhastobewashedthoroughlywithwater.Itisstronglyadv |
UsageRecommendations | Tobeoptimizedbytheenduser. |
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BIOLOGicalSignificance | ThisgeneencodesamemberoftheF-boxproteinfamilywhichischaracterizedbyanapproximately40aminoacidmotif,theF-box.TheF-boxproteinsconstituteoneofthefoursubunitsofubiquitinproteinligasecomplexcalledSCFs(SKP1-cullin-F-box),whichfunctioninphosphorylation-dependentubiquitination.TheF-boxproteinsaredividedinto3classes:FbwscontainingWD-40domains,Fblscontainingleucine-richrepeats,andFbxscontainingeitherdifferentprotein-proteininteractionmodulesornorecognizablemotifs.TheproteinencodedbythisgenebelongstotheFblsclassand,inadditiontoanF-box,containsatleast9tandemleucine-richrepeats. |
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