Fitzgerald/PML antibody/10R-1742/50 ug,Fitzgerald,,Fitzgerald,fitzgerald-fii,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Fitzgerald/PML antibody/10R-1742/50 ug

产品编号：10R-1742-50ug

市场价：¥8920.00

场地：美国(厂家直采)

产品分类：抗体类>一抗>单克隆抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$446.00

品牌： Fitzgerald

公司：Fitzgerald,Inc.

公司分类：

商品介绍

OVERVIEW:

Synonyms	Monoclonal PML antibody, Anti-PML antibody, PP8675 antibody, Anti PML antibody, MYL antibody, Promyelocytic leukemia antibody, TRIM19 antibody, TRIM19 antibody, RNF71 antibody, PML antibody, Promyelocytic leukemia antibody, PP8675 antibody, MYL antibody, RNF71 antibody
Specificity	Human PML
Cross Reactivity	Human. Other species not studied
Applications	Dot Blot, ICC
Immunogen	PML antibody was raised in mouse using recombinant Human Promyelocytic Leukemia

SPECIFICATIONS:

Host	Mouse
Clone	880C3a
Isotype	IgG1
Method of Purification	PML antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Form & Buffer	PML antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3 ).
Concentration	100 ug/ml

STORAGE & SAFETY:

Storage	Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing.
Biohazard Information	This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv

Usage Assay Information:

Usage Recommendations	To be optimized by the end user.

GENERAL INFORMATION:

Biological Significance	The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.

Biological Significance

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.

品牌介绍

Fitzgerald公司始于1989年，是全球著名的抗体、蛋白及其他科研试剂生产商。可提供超过45,000种产品，可为科研机构、诊断机构和制药公司提供包括单抗、多抗、天然和重组蛋白、ELISA试剂盒等多种试剂。
Fitzgerald的特色产品有PSA蛋白； CA 125, CA 15-3, CA 19-9 和 CA 50 抗体, GAPDH 抗体；Influenza单抗；心肌标志物如CKMM蛋白和Apo抗体；激素和类固醇多抗如**(testosterone)抗体, 孕酮(progesterone)抗体,和甲状腺素(thyroxine)抗体。

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