Synonyms | MonoclonalpanCytokeratinantibody,Anti-panCytokeratinantibody |
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CrossReactivity | Human |
Applications | ELISA,IF,IHC |
Immunogen | panCytokeratinantibodywasraisedinMouseusingapurifiedrecombinantfragmentofCytokeratin5expressedinE.coliastheimmunogen. |
Host | Mouse |
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Clone | 7H8 |
Isotype | IgG1 |
Form&Buffer | Suppliedasaliquidinasciticfluidcontaining0.03%sodiumazide. |
Concentration | 1.0mg/ml |
Storage | Storeat4degCforshorttermstorage.Storeat-20degCforlongtermstorage.Avoidrepeatedfreeze/thawcycles. |
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UsageRecommendations | ELISA:1:10,000,IF:1:200-1:1000,IHC:1:200-1:1000 |
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BIOLOGicalSignificance | Biochemically,mostmembersoftheCKfamilyfallintooneoftwoclasses,typeI(acidicpolypeptides)andtypeII(basicpolypeptides).ThetypeIIcytokeratinsconsistofbasicorneutralproteinswhicharearrangedinpairsofheterotypickeratinchainscoexpressedduringdifferentiationofsimpleandstratifiedepithelialtissues.Cytokeratinscompriseadiversegroupofintermediatefilamentproteins(IFPs)thatareexpressedaspairsinbothkeratinizedandnon-keratinizedepithelialtissue.Cytokeratinsplayacriticalroleindifferentiationandtissuespecializationandfunctiontomaintaintheoverallstructuralintegrityofepithelialcells.CytokeratinshavebeenfoundtobeusefulMarkersoftissuedifferentiationwhichisdirectlyapplicabletothecharacterizationofmalignanttumors. |
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Fitzgerald公司始于1989年,是全球著名的抗体、蛋白及其他科研试剂生产商。可提供超过45,000种产品,可为科研机构、诊断机构和制药公司提供包括单抗、多抗、天然和重组蛋白、ELISA试剂盒等多种试剂。
Fitzgerald的特色产品有PSA蛋白; CA 125, CA 15-3, CA 19-9 和 CA 50 抗体, GAPDH 抗体;Influenza单抗;心肌标志物如CKMM蛋白和Apo抗体;激素和类固醇多抗如**(testosterone)抗体, 孕酮(progesterone)抗体,和甲状腺素(thyroxine)抗体。