Synonyms | Monoclonal EGFR antibody, anti-EGFR antibody, HER1 antibody, PIG61 antibody, Proto-oncogene c-ErbB-1 antibody, Cell growth inhibiting protein 40 antibody, epidermal growth factor receptor antibody, Oncogene ERBB antibody, Avian erythroblastic leukemia viral (verbb) oncogene homolog antibody, ERBB antibody, Urogastrone antibody, Epidermal growth factor receptor antibody, ERBB1 antibody, Cell proliferation inducing protein 61 antibody |
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Specificity | Human |
Applications | ELISA, ICC, WB |
Immunogen | EGFR antibody was raised in mouse using recombinant human EGFR (424-605aa) purified from E. coli as the immunogen. |
Host | Mouse |
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Clone | AT6E3 |
Isotype | IgG2b kappa |
Method of Purification | EGFR antibody was purified by protein G affinity chromatography. |
Form & Buffer | Supplied in liquid form in Phosphate-Buffered Saline, pH 7.4 with 0.1% Sodium Azide. |
Concentration | 1 mg/ml |
Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
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Usage Recommendations | ELISA, ICC, WB, ELISA: 1:250, ICC: 1:250, WB: 1:250 |
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Biological Significance | Epidermal growth factor receptor (EGFR) is a 170 kDa membrane protein first identified as a binding partner of EGF. Also, EGFR phosphorylated itself (autophosphorylation) in response to EGF treatment. The overexpression of EGFR in various epithelial tumors was widely reported and it has been substantiated that deregulation of EGFR itself and its signaling pathways an important role in human cancers. |
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Fitzgerald公司始于1989年,是全球著名的抗体、蛋白及其他科研试剂生产商。可提供超过45,000种产品,可为科研机构、诊断机构和制药公司提供包括单抗、多抗、天然和重组蛋白、ELISA试剂盒等多种试剂。
Fitzgerald的特色产品有PSA蛋白; CA 125, CA 15-3, CA 19-9 和 CA 50 抗体, GAPDH 抗体;Influenza单抗;心肌标志物如CKMM蛋白和Apo抗体;激素和类固醇多抗如**(testosterone)抗体, 孕酮(progesterone)抗体,和甲状腺素(thyroxine)抗体。