Synonyms | Monoclonal p14 ARF antibody, Anti-p14 ARF antibody, ARF, CD2A1, CDK4 inhibitor p16-INK4, CDK4I, CDKN2, CDKN2A, cell cycle negative regulator beta, CMM2, Cyclin-dependent kinase 4 inhibitor A, cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4), cyclin-dependent kinase inhibitor 2A, isoform 4, Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3, cyclin-dependent kinase inhibitor p16, INK4, INK4a, MLM, MTS-1, MTS1, Multiple tumor suppressor 1, p14, p14ARF, p16, p16-INK4, p16-INK4a, p16INK4, p16INK4A, p19, p19Arf, TP16 antibody |
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Specificity | Human |
Applications | ELISA, IF, IHC, IP, WB |
Immunogen | p14 ARF antibody was raised in Mouse using His-tagged p14ARF protein expressed in bacteria as the immunogen |
Host | Mouse |
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Clone | ARF 4C6/4 |
Isotype | IgG2a |
Method of Purification | p14 ARF antibody purified by affinity chromatography |
Form & Buffer | Supplied as liquid in PBS with 0.02% sodium azide |
Concentration | 1 mg/ml |
Storage | Store as concentrated solution. Aliquot and store at -20 deg C or below. Avoid repeated freeze-thaw cycles. |
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Biological Significance | p14 ARF is a cell-cycle regulatory protein that interacts with CDK4 and CDK6, inhibiting their ability to interact with cyclins D. Inhibits the phosphorylation of the retinoblastoma protein by CDK4 or CDK6, and entry into the S phase of the cell cycle. |
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Fitzgerald公司始于1989年,是全球著名的抗体、蛋白及其他科研试剂生产商。可提供超过45,000种产品,可为科研机构、诊断机构和制药公司提供包括单抗、多抗、天然和重组蛋白、ELISA试剂盒等多种试剂。
Fitzgerald的特色产品有PSA蛋白; CA 125, CA 15-3, CA 19-9 和 CA 50 抗体, GAPDH 抗体;Influenza单抗;心肌标志物如CKMM蛋白和Apo抗体;激素和类固醇多抗如**(testosterone)抗体, 孕酮(progesterone)抗体,和甲状腺素(thyroxine)抗体。